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Croda International Plc d 7 glucosylsphingosine
Structures of lyso-PAFs and primary storage substances of LSDs investigated in this study. (A) Three major lyso-PAF species: lyso-PAF(16:0), lyso-PAF(18:1), and lyso-PAF(18:0). (B) Lyso-sphingomyelin accumulated in NPA. (C) Pentasaccharide H3N2b accumulated in GM1. (D) C18:0 ganglioside GM2 accumulated in TSD and SD. (E) Galactosylsphingosine accumulated in KD. (F) <t>Glucosylsphingosine</t> accumulated in GD.
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Structures of lyso-PAFs and primary storage substances of LSDs investigated in this study. (A) Three major lyso-PAF species: lyso-PAF(16:0), lyso-PAF(18:1), and lyso-PAF(18:0). (B) Lyso-sphingomyelin accumulated in NPA. (C) Pentasaccharide H3N2b accumulated in GM1. (D) C18:0 ganglioside GM2 accumulated in TSD and SD. (E) Galactosylsphingosine accumulated in KD. (F) Glucosylsphingosine accumulated in GD.

Journal: Molecular genetics and metabolism

Article Title: Secondary accumulation of lyso-platelet activating factors in lysosomal storage diseases

doi: 10.1016/j.ymgme.2025.109180

Figure Lengend Snippet: Structures of lyso-PAFs and primary storage substances of LSDs investigated in this study. (A) Three major lyso-PAF species: lyso-PAF(16:0), lyso-PAF(18:1), and lyso-PAF(18:0). (B) Lyso-sphingomyelin accumulated in NPA. (C) Pentasaccharide H3N2b accumulated in GM1. (D) C18:0 ganglioside GM2 accumulated in TSD and SD. (E) Galactosylsphingosine accumulated in KD. (F) Glucosylsphingosine accumulated in GD.

Article Snippet: Lyso-sphingomyelin, d 7 -lyso-sphingomyelin, glucosylsphingosine, d 7 -glucosylsphingosine, galactosylsphingosine, and d 7 -galactosylsphingosine were purchased from Avanti Research (Birmingham, AL).

Techniques:

Lyso-PAFs and glucosylsphingosine in cortexes of GD patients and control subjects. (A) Lyso-PAF(16:0), lyso-PAF(18:1), and lyso-PAF(18:0) in cortexes of controls (n = 3), GD1 ( n = 5), GD2 (n = 3), and GD3 ( n = 1) patients. (B) Glucosylsphingosine in cortexes of controls (n = 3), GD1 (n = 5), GD2 (n = 3), and GD3 (n = 1) patients. Lyso-PAF and glucosylsphingosine concentrations are presented as mean ± standard error of the mean (SEM). Data comparison for Lyso-PAF and glucosylsphingosine in controls, GD1, and GD2 was performed with Kruskal-Wallis test with Dunn’s multiple comparisons test as post hoc test. The statistical comparison of GD3 with other groups was not performed due to the small sample size of GD3. ns: not significant; ns: not significant; *: p < 0.05; **: p < 0.01.

Journal: Molecular genetics and metabolism

Article Title: Secondary accumulation of lyso-platelet activating factors in lysosomal storage diseases

doi: 10.1016/j.ymgme.2025.109180

Figure Lengend Snippet: Lyso-PAFs and glucosylsphingosine in cortexes of GD patients and control subjects. (A) Lyso-PAF(16:0), lyso-PAF(18:1), and lyso-PAF(18:0) in cortexes of controls (n = 3), GD1 ( n = 5), GD2 (n = 3), and GD3 ( n = 1) patients. (B) Glucosylsphingosine in cortexes of controls (n = 3), GD1 (n = 5), GD2 (n = 3), and GD3 (n = 1) patients. Lyso-PAF and glucosylsphingosine concentrations are presented as mean ± standard error of the mean (SEM). Data comparison for Lyso-PAF and glucosylsphingosine in controls, GD1, and GD2 was performed with Kruskal-Wallis test with Dunn’s multiple comparisons test as post hoc test. The statistical comparison of GD3 with other groups was not performed due to the small sample size of GD3. ns: not significant; ns: not significant; *: p < 0.05; **: p < 0.01.

Article Snippet: Lyso-sphingomyelin, d 7 -lyso-sphingomyelin, glucosylsphingosine, d 7 -glucosylsphingosine, galactosylsphingosine, and d 7 -galactosylsphingosine were purchased from Avanti Research (Birmingham, AL).

Techniques: Control, Comparison